Herbal Medicines by Akio Inui

Author:Akio Inui
Language: eng
Format: epub
Publisher: Springer New York, New York, NY

The effects of rikkunshito on gastric adaptive relaxation have been reported in isolated guinea pig stomachs [21], conscious dogs [22], and isolated fundus smooth muscle from Suncus murinus [23] and diabetic neuropathic rats with gastric dysmotility [20]. Rikkunshito not only increased gastric adaptive relaxation at the basal level but also ameliorated inhibited relaxation by the nitric oxide synthase inhibitor [20]. Improvement in gastric accommodation was also reported in virtual reality stress-imposed healthy humans [24].

Rikkunshito was reported to stimulate gastrointestinal contractions in the interdigestive state and gastric emptying in conscious dogs through cholinergic neurons and serotonin type-3 receptors [25]. The prokinetic effect of rikkunshito by 5-HT3 receptor antagonism was also reported in delayed gastric emptying induced by either nitric oxide synthase inhibitor [16] or serotonin [26].

Recently, Herbrechter et al. [27] analyzed the antagonistic effects of the rikkunshito constituents at heterologously expressed 5-HT3A receptors using the two-electrode voltage-clamp technique. They showed that ethanol tinctures from Aurantii, Ginseng, Zingiberis, Atractylodis, and Glycyrrhiza inhibited the 5-HT3A receptor response; among them, the strongest antagonism was found for Glycyrrhiza. Liquiritigenin, glabridin, and licochalcone A from Glycyrrhiza and hesperetin which are the aglycone of hesperidin from Aurantii were found to be the most effective inhibitors of the 5-HT-induced currents in the screening .

Download

Copyright Disclaimer:
This site does not store any files on its server. We only index and link to content provided by other sites. Please contact the content providers to delete copyright contents if any and email us, we'll remove relevant links or contents immediately.